The Influence of Carbofuran on Purkinje cells death in the fetal cerebellum of mice (Mus Musculus)
Department of Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, Indonesia.
Research Article
Open Access Research Journal of Biology and Pharmacy, 2024, 10(01), 010–015.
Article DOI: 10.53022/oarjbp.2024.10.1.0007
Publication history:
Received on 15 December 2023; revised on 23 January 2024; accepted on 26 January 2024
Abstract:
The objective of this research was to assess the extent of damage to cerebellar Purkinje cells in fetal mice caused by exposure to the insecticide carbofuran during the embryonic period. The study involved eighteen pregnant female mice (Mus Musculus) exposed to carbofuran from gestational days 14 to 17. The female mice were divided into three groups: P0 (treated with physiological NaCl solution), P1 (treated with carbofuran at 0.0208 mg/Kg/day), and P2 (treated with carbofuran at 0.0417 mg/Kg/day). The data were analyzed using ANOVA and followed by the BNJ test. The results indicated a significant difference, with an increase in Purkinje cell necrosis corresponding to the dose of carbofuran.
Keywords:
Carbofuran; Purkinje cell; Necrosis; Pesticide stress
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