L18R a peptide with potential against melanoma
Experimental Oncology Unit, Department of Microbiology, Immunology and Parasitology, Federal University of São Paulo, São Paulo, SP, Brazil.
Research Article
Open Access Research Journal of Biology and Pharmacy, 2022, 04(02), 022–027.
Article DOI: 10.53022/oarjbp.2022.4.2.0038
Publication history:
Received on 07 march 2022; revised on 12 April 2022; accepted on 14 April 2022
Abstract:
Peptides have fantastic functions like defensins that make up the natural defense in different species from vertebrates to bacteria. Another fantastic example are prions that cause transmissible diseases devoid of nucleic acid. So, because of their high specificity, peptides can be used for different therapeutic goals. In this work we describe in vitro action of a peptide named L18R this sequence is part of a group of four distinct sequences that were previously tested and showed activity against fungi and tumors, which motivated us to investigate this activity against murine B16F10 melanoma. Thus, has been demonstrated that L18R had activity against tumor, for interfering in cell viability, migration and in cell cycle. To conclude, the present work suggests a functional molecule against tumor.
Keywords:
Peptide; Antitumor activity; Cell cycle; B16F10 melanoma; Aggressive tumor cells; Cell migration
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Copyright © 2022 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0