Optimised herbal transdermal patch of ethnobotanical plant Costus igneus N. E. br. Developed through response surface methodology
Department of Pharmaceutical Technology, Bengal School of Technology, Sugandha, Chinsurah, Hooghly, West Bengal, Pin-712102, India.
Research Article
Open Access Research Journal of Biology and Pharmacy, 2023, 09(02), 041–056.
Article DOI: 10.53022/oarjbp.2023.9.2.0055
Publication history:
Received on 04 October 2023; revised on 22 November 2023; accepted on 25 November 2023
Abstract:
Costus igneus (Family: Costaceae) has been used by the aboriginal humans since long through oral route. In our laboratory, we used biodegradable polymer for release control of this transdermal patch. This transdermal patch could be affixed in the lower abdominal region which releases intraperitoneally after principal meals, twice a day; which could be terminated instantly by removing the patch externally. Our objective is Formulation, evaluation and statistical designing of a Transdermal patch containing ethnobotanical plant Costus igneus. As Transdermal Patch reduces can be removed when termination of treatment is necessary and it also has the capability to bypass the different chemical changes that a oral pill has to go through.
The Macro-physico evaluation parameters were calculated. The folding endurance was in between of 7 to 16, the maximum value was of the FOPT, the Tensile strength was relatively similar in all the formulations. FOPT showed the highest of all. In percentage elongation test the FOPT showed good resilience, thickness was relatively acceptable for all the formulations. % moisture content and %moisture uptake was acceptable in all of the formulations showed a good and satisfiable range. The drug content was calculated according the total quercetin content taking pure quercetin API as the reference FOPT had the highest drug content of 82.5%. The Response Surface Curve predicted the optimised formulation and the desirability score also gives us our optimised patch. The Kinetics for the optimum by the optimization of transdermal patch was observed in all the different type of plots. The FOPT had a good linearity of 0.938 in regression co-efficient with Korsmeyer-Peppas Plot . It explains the release of drug’s material through a polymeric matrix system while also considering Non-Fickian drug release mechanism. The different Response Surface Curve allows us to predict from the software that the FOPT Formulation is the Gem of Ten. This would produce beneficial blood-sugar content reduction. If we can commercialise this Herbal Transdermal Patch then, it can be an innovation remedy for this chronic disease.
Keywords:
Transdermal Patch; Factorial design; Drug Delivery System; Dose dependent response; Biodegradable; Homo-polymer; Pharmaceutics
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