Spectroscopy of the thrombin-aptamer interaction: A review
1 Department of Oral and Maxillofacial Surgery, The Dental College of Georgia at Augusta University, Augusta, GA, USA.
2Dental School, Belarusian Medical University, Minsk, Belarus.
3 Post Graduate of Oral and Maxillofacial Medicine, Dental School, Tehran University of Medical Sciences, Tehran, Iran.
4 Department of Orthodontics, Georgia School of Orthodontics, Atlanta, Georgia, USA.
Review
Open Access Research Journal of Biology and Pharmacy, 2023, 07(01), 038–042.
Article DOI: 10.53022/oarjbp.2023.7.1.0012
Publication history:
Received on 15 December 2022; revised on 29 January 2023; accepted on 31 January 2023
Abstract:
Thrombin is considered an adaptable enzyme, and it has a major role in the process of injured vessel hemostasis. Hence, the detection of thrombin is crucial in the course of any illness. Aptamers, a class related to functional molecules, are short artificial oligonucleotides that are being widely used in protein sensors as recognition elements. Tracking and detection of different biomolecules is crucial not just in the medical diagnostics field but in biotechnology and biological research, biodefense, drug discovery, drug design, and environmental monitoring as well. Direct detection methods, including surface plasmon resonance spectroscopy and mass spectrometry, are also extensively utilized for the detection of thrombin-aptamer interactions. We summarize the studies on spectroscopy and the thrombin-aptamer interaction in this review.
Keywords:
Thrombin; Aptamers; Spectroscopy; Hemostasis
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Copyright © 2023 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0