Prevalence of transfusion-transmissible infections among Blood Donors Attending the Regional Hospital Center of Franceville (Southern Gabon)
1 Department of Biology, Laboratory of Molecular and Cellular Biology (LABMC), Faculty of Sciences, University of Science and Technology of Masuku (USTM), Franceville, Gabon.
2 Amissa Bongo Regional Hospital Center of Franceville (CHRAB), Clinical Laboratory, Gabon.
3 Department of Chemistry, Biochemistry Research Laboratory (LAREBIO), Faculty of Sciences, University of Science and Technology of Masuku (USTM) Franceville, Gabon.
4 Mouila Regional Hospital Center, Clinical laboratory, Gabon.
Research Article
Open Access Research Journal of Biology and Pharmacy, 2023, 09(02), 014–020.
Article DOI: 10.53022/oarjbp.2023.9.2.0054
Publication history:
Received on 03 October 2023; revised on 21 November 2023; accepted on 24 November 2023
Abstract:
Background: Transfusion transmissible infections (TTI) constitute a worldwide threat to blood donation, especially in developing countries.
Objective: To determine the prevalence of HIV, hepatitis C virus (HCV), hepatitis B virus (HBV), and Treponema palladium among prospective blood donors attending the Amissa Bongo Regional Hospital Center of Franceville (ABRH).
Methods: CTKBiotech test strips were used to detected blood transmissible infections. Antibodies to HIV ½ (HIV), hepatitis C virus (HCV), Hepatitis B virus (HBV) and T.pallidium were detected using respectively OnSite HIV 1/2 Ab Plus Combo Rapid Test, the OnSite HCV Ab Plus Combo Rapid Test, the OnSite HBsAg Combo Rapid Test, the OnSite Syphilis Ab Rapid Test.
Results: A total of 447 prospective blood donors attending the ABRH was included in this study. The age ranged between 18 and 50 with a median age of 30. Male and family donors made up more than 88% and 83% of the study population, respectively. HBV was the most prevalent TTI with 2.68%, follow by HIV, HCV, and Syphilis, with respectively 2.23%, 1.56%, and 0.89%.Among the examined blood transmissible pathogens, only HIV was significantly associated with unemployment. Females were 3.47, 1.3, and 2.62 times more prone to test positive to respectively HIV, HCV, T.pallidium compared to males. None of the risk factors considered in this study was significantly associated with any transfusion transmissible infection.
Conclusion: The present results confirm the declined of syphilis among blood donors in Gabon. Co-infection cases reported here raises concerns as they are known to complicate the patient care.
Keywords:
Blood donors; Hepatits; HIV; Treponema palladium; Transfusion transmissible infection
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